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Part III of the video series MTHFR and Homocysteine picks up where the parts I & parts II leave off.  In those previous videos, I’ve already outlined where homocysteine comes from and the multiple ways it can damage our bodies.  You can review those ideas anytime by watching parts I and II.  In this third video you will learn to see evidence of brain problems on the outside of the body.  By knowing what to look for in the hands and feet, you can learn how to see brain problems with the naked eye.  Very cool stuff!

While homocysteine is a problem, it can be relatively simple to manage.  Methylation nutrients play a major role in keeping this system balanced.  We already know that SNPs such as PEMT, BHMT, MTR, MTRR, MTHFR and AHCY increase homocysteine levels and impair methylation processes in the brain.  By making sure you have enough folate, b12, trimethylglycine, betaine, and choline you can work around these SNPs, optimizing brain health.  These nutrients are necessary to keep homocysteine levels from rising too high.  The best part is that the current, peer-reviewed research agrees with the above.

Everything from epilepsy, brain fog and depression (all brain-related conditions) are involved with neuro-inflammation.  As the previous videos have shown homocysteine is a key player in brain inflammation and neurodegeneration.  If we balance homocysteine we’ve fixed a large part of the problem.  Recent studies prove that B-vitamins (methyl donors) protect the brain from degeneration, mainly through balancing homocysteine levels.  Remember that homocysteine rises when:

  • SNPs are present that slow down the recycling and/or the transulfuration of homocysteine.  SNPs are often said to mimic dietary deficiency of methyl groups.  Meaning, SNPs slow down the chemistry in the same way that dietary deficiencies do.
  • Diets are deficient in methyl groups – aka Standard American Diet.  Since folate is named after “foliage” which means green leafs it doesn’t take a PhD to realize that most people don’t eat enough plants and therefore don’t get enough folate from their food.  This causes homocysteine to rise and leads to neurodegeneration.
  • Homocysteine SNPs and poor diet are both going on at the same time.  This is the worst of both worlds, but still fixable by changing habits and nutritional levels.
  • Toxins, Heavy Metals, and Stress all increase inflammation in the brain and forces the body to produce more glutathione.  As the body runs out of glutathione, homocysteine rises.  This is a common problem and again is fixed by proper metabolic detoxification, glutathione support and of course methylation support.

So any of these problems listed above will raise homocysteine.  It is cured through detoxification, healthy eating, lifestyle and stress management, and individualized supplementation with proper methylation support.  In other words, natural medicine when properly applied makes these problems go away or improve a great deal.  And pay attention to the skin of the hands and feet as that is a direct reflection of the health of the brain.

The first thing to notice is if someone has poor circulation in their hands or feet.  The microvasculature (small blood vessels) that bring blood to the extremities are the same which bring blood to the brain.  We can say then that poor circulation in small vessels of the extremities indicates poor circulation in the brain – the same small vessels deliver blood to both areas.  On the other hand, if someone has very dry, cracked skin on their hands and feet that is almost always due to Omega 3 and essential fatty acid deficiency.  The fats required to build and maintain a healthy brain, are also necessary to keep the skin from cracking, bleeding and being excessively dry.  You can take it to the bank that if someone has a deficiency of fat or circulation in their hands and feet, they also have a deficiency in their brain!

Methylation science is complicated but it doesn’t have to be.  We are always making things more difficult and confusing than is necessary.  We can fix so many brain problems that are destroying people’s lives simply by treating the root cause – balancing methylation.  That is the take away message I hope you get from this third MTHFR and Homocysteine video.  Don’t let the information scare you.  Let it inspire you to make a positive change!

In Health,

Dr. Rostenberg

7 Comments

  • June 22, 2014 Reply

    John Bennett

    Fantastic MTHFR Series! Thank you!

    • June 23, 2014 Reply

      drrostenberg

      Thank You John. I appreciate your feedback. Stay tuned for more info on MTHFR coming soon! – Dr. Rostenberg

  • October 22, 2014 Reply

    San Diego Lead Maker

    This site is fantastic. Answers sooooo many of my questions plus educates me further.

    • October 22, 2014 Reply

      drrostenberg

      Thank You Kate for the very kind and positive feedback. We will soon have a new site with all this information organized even better for you. Stay tuned as we will also be starting seminars and learning modules in 2015 to help educate even more. Yours in Health, Dr. Rostenberg

  • October 26, 2014 Reply

    Santiago

    Dr. Rostenberg,

    after learning on methylation isssues I got the impression that homocysteine can be decreased with appropiate methylation support, in line with your videos. However, I’ve been trying to decrease my homocysteine through heavy supplementation with methyl donors (Metafolin 2x800mcg + 400mcg 5-MTHF+2000mcg sublingual Methylcobalamin+7500mg/TMG) to correct my SNPs with no results. My homocysteine has passed from 9.2 to 10.2 after 6 months of supplementation.

    Please, do you have an indication of what can be wrong?. I have high lp(a), and add
    high homocysteine is awful for atherosclerosis.

    Thanks. Santiago

    Basic genetic data:
    – APOE 3/3.
    – Heterozygous (+-): A1298C, C677T, CBS A13637G, CBS A360A, CBS C19150T, CBS C699T, COMT V158M, COMT H62H, BHMT-08 (rest of BHMT all good: ‘- -‘)
    – Homozygous (++): VDR Tak, MAO A R297R

    • October 27, 2014 Reply

      drrostenberg

      Hi Santiago,

      I suggest you consider that you may be deficient in B6 and cysteine, since both are able to lower homocysteine through transulfuration reactions. You obviously are taking enough methyl folate and B12…but that may not be the whole picture. If you are lacking B2 you cannot make FAD which is a cofactor for MTHFR, so MTHFR slows down. But that shouldn’t be an issue with all the methyl groups you are taking. I suspect you have a SLOWED CBS which needs to be supported through the transulfuration pathway. It can be very hard to figure this all out on your own. If you would like my help please contact my office at 208-322-7755 or email us at redmountainclinic@gmail.com. In Health, Dr. Rostenberg

  • October 27, 2014 Reply

    Santiago

    Dr. Rostenberg,

    thanks a lot for your help. I really appreciate it.
    I made a typo: it’s 750mg TMG, no 7500mg!.

    As for cysteine I’m taking 1pill of 600mg of Jarrow’s NAC.
    Anyway, I’ll contact you for a consultation because probably will be the better route.

    Thanks. Santiago

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