Have you ever wondered how to find out if someone has a methylation problem? Well you have probably heard to doing saliva or blood tests to see which genes a person was born with.  And that is certainly one way to figure out if someone has a methylation problem.  Tests like that are valuable but they can be time consuming and a bit expensive as well.  So I’d like to share with you a better and faster way to figure out if someone you  know has a methylation problem.

First, allow me to quote one of my favorite pieces of research:

“Folate metabolism can influence the final form of any growing tissue due not only to its participation in nucleic acid synthesis, but also to its known function in regulating DNA and protein methylation.”  – Bio Med Central Medical Genetics. 2011 May 26;12:75.

Folate, ie mother nature’s #1 methyl donor, can impact the final form of any growing tissue in the body!  That is proof positive that the methylation cycle can not only afffect how you FEEL but it can also affect how you LOOK.  In fact, as the video below explains, there are all kinds of physical signs that point to methylation problems.


Each of the following health conditions and physical characteristics suggests a methylation problem is at play:

  • Epicanthal folds, hypertelorism, low set ears
  • Neural tube defects of all kinds,  incl. spina bifida
  • Down’s Syndrome
  • Fetal Alcohol Syndrome
  • Klienfelter’s Syndrome
  • Marfan’s Syndrome
  • All other trisomies and anueploidies
  • Cleft palate
  • Austism spectrum
  • Arnold-Chiari Malformation
  • Short limbs
  • Scoliosis
  • Any midline defect present at birth
  • Essentially all congenital abnormalities

Do you know anyone in your life who has some of the issues discussed in that video or listed in this article?  If so, they need to work on balancing their methylation cycle and should be working with a professional who is knowledgeable about this type of health concern.  You may find a practitioner in your area from MTHFRsupport.com.

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  • July 30, 2014 Reply

    Chanon Starnes

    HI Dr. Rostenberg, I recently found out I may have the MTHFR gene defect. I am currently in the process of getting the genetic test results. My question is for my 15 year old daughter.. We discovered her scoliosis at age 13..she has two curves the thoracic being the more severe one. She also has the long fingers and is a very thin frame. I am planning to get the genetic test for her. Based on your research, it is too late for her scoliosis if we do find she has the defect too? Have you come across any cases where the scoliosis improved with supplementation and diet?

    Thank you so much for your work!
    Chanon Starnes

    • July 31, 2014 Reply


      Hi Chanon,

      I recommend the Clear Institute for all questions related to scoliosis. The Clear Institute is the leader in treating scoliosis once it has been discovered. She likely has a genetic component to her scoliosis and I can help you support her nutritionally to prevent other issues from showing up. The description of the long fingers, etc., are consistent with the “methylation” phenotype. Regardless of which genes she has, she can find an optimum balance and get better. For treating the scoliosis once it is already present in the spine, you need to reach out to the experts in the chiropractic field, the Clear Institute. For the genetic support and methylation support, I can help you with that directly. If you have any questions please contact my office redmountainclinic@gmail.com and 208-322-7755. Thank You. Dr. Rostenberg

  • November 22, 2016 Reply

    Kara Bell

    Hi Dr. Rostenberg-
    Do you do Consults? I am Homozygous for the MTHFR gene and my 11 year old was born with a Cleft Palate. I’m beginning to think this is related and want to learn more. How should I be supplementing my son? Also, I was in Pharmaceutical/Medical Sales for 10 years and this was never talked about in the OB/GYN community when I was working in it. Crazy to think that some Cleft Palates could be avoided if there was proper education.

    • December 26, 2016 Reply


      Hi Kara,

      Thanks for your comment. I perform consults all the time. We work with patients all over the country and from 20 different countries around the world. Cleft palate is a midline defect, which is heavily related to methylation imbalances during gestation. So from that point of view your son needs a high quality multivitamin with activated folate (I recommend Metagenic’s Phytomulti (2) per day). In addition he should eat organic as much as possible, and of course lots of green veggies! If I can be of service in any way to you or your family, then don’t hesitate to contact my office. 208-322-7755 and care@redmountainclinic.com.

      Yours in Health,

      Dr. Rostenberg

  • December 6, 2016 Reply


    Chiropractic care reduces scoliosis significantly. Easier to correct the younger the person is.

    • December 26, 2016 Reply


      Yes! Get your family into chiropractic care and the earlier you get your body adjusted, the more powerful and lasting the effects. I adjust my entire family and have been taking care of my children since birth. In a better world, everyone would get access to the amazing power of chiropractic care. Add to that the latest science of functional medicine, methylation and epigenetics and you have the opportunity to really help individuals reach the peak of the health and potential.

      In Health,

      Dr. Rostenberg

  • December 20, 2016 Reply


    Hi Dr. Rostenberg,

    Please can I ask if paradoxical vocal chords at birth would be considered a midline defect? My fiends son has just turned one and is still unable to breath alone unaided. They are waiting for his myelin sheath to develop on the vocal chords, despite him now being able to stand suggesting it is developing elsewhere in the body. Mother was vegetarian whilst pregnant and ate fish. As B12 and folate are required in the production of myelin sheath I feel the doctors should be testing for MTHFR and treating him as such?
    Thank you

    • December 26, 2016 Reply


      Hi Katy,

      Thanks for your comment. Yes, in theory all midline defects are methylation-related. There isn’t a ton of research to confirm this, but from the research we have any tissue which malforms during gestation is related to methylation. Vocal cords are formed from the pharyngeal arches during development, which is a midline structure related to formation of the mouth, face, tongue, etc. All these tissues have known methylation-related problems, so its not much a stretch to see another part of the pharyngeal arch be impacted by MTHFR genes. If not already discussed, it may be of value to look at cranial/sacral and pediatric chiropractic. There may be malformations which are putting pressure on cranial nerves (Vagus N., Hypoglossal, etc.) or birth trauma which can also be improved by structural work. Hope that helps!

      In Health,

      Dr. Rostenberg

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