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The health of the gut determines the health of the body.  This is a well-known fact.  There are roughly 100 trillion cells inside our bodies, yet the there about 10x as many cells of bacteria living on our bodies.  This mass of bacteria lives in harmony with us (most of the time) and helps make sure our immune system is functioning and we are able to digest our food.   Without these bacteria in our gut and on our skin, we wouldn’t survive long.

That is all good news but what happens when these bacteria become imbalanced?  What are the implications to our health when we have an overgrowth of bacteria in the gut?  As we will see, when the small intestine is overwhelmed with bacteria (diagnosed as Small Intestine Bacterial Overgrowth – SIBO) it can have major impacts on our methylation cycle…it can make methylation problems much worse!

As a quick reminder, those of us with MTHFR, PEMT, MTR, MTRR, etc. have defects in how well we recycle homocysteine and how well we convert folic acid into folate.  Many of you are aware of Dr. Lynch and his concept that folic acid is a toxin for those with MTHFR.  While there is still some debate about this issue, Dr. Lynch is right on when he points out that having too much folic acid can impair the methylation cycle.  Here is how it works:

1) Folic acid comes from fortified food AND from gut bacteria.  Yes, you heard that right…folic acid is a NATURAL by product of the metabolism of bacteria that live in our intestines, mainly the colon.  Every person on earth gets some folic acid into their bodies from the action of our gut bacteria.

We get in trouble when the bacteria in our colon grows and moves into the small intestine.  Normally only a small amount of bacteria is found in the small intestine, but when the digestive system becomes imbalanced the population of bacteria in the small intestine can increase, creating a condition of SIBO.

2) Folic acid and folate both enter the cell through the same receptor.  If there is an excess of folic acid, it is harder for the folate to get into the cell.  The more folic acid you have inside your blood stream, the less often folate will get to the receptor.  In other words, there is competition between folic acid and folate, and when folic acid is elevated, it wins the competition to enter the cell.

3) In a person WITHOUT MTHFR issues, this poses zero problems since folic acid is rapidly converted to folate in their methylation cycle.  For the rest of us however excess folic acid makes it harder for us to create methyl donors.  Since MTHFR is often slowed down along with MTR, MTRR, BHMT and other SNPs, having high doses of folic acid may slow down the methylation cycle.  This is why folic acid in high amounts can be a problem.

There is new research that shows that the bacteria involved with SIBO actually poop out large amounts of folic acid (yes the dreaded folic acid!) and we absorb that folic acid into our bodies.  Many individuals with MTHFR C677T/A1298C, MTR, BHMT, etc. may have symptoms of under- or overmethylation due solely to the excess folic acid from improper gut bacteria and digestion.  An imbalance of the gut bacteria, namely in the small intestine, is a major reason WHY an individual has elevated unmetatoblized folic acid.  If we are going to balance methylation pathways, we need to control how much folic acid gets into the system. – we have to control the gut!

In other words, until the gut infection is properly taken care of, the methylation cycle is at the mercy of what is happening in the gut.  The same is true of important vitamins like choline, B12, vitamin D, protein, etc…the gut imbalance makes it very difficult to absorb these vitamins.  Side effects from vitamins are most commonly due to an untreated gut problem.

When someone has SIBO, or an overgrowth of “non-pathogenic” (aka normal species of gut flora) bacteria in the small intestine, the bacterial infection can produce EXCESS AMOUNTS OF FOLIC ACID!  Too many bacteria in your gut, can lead to way too much folic acid being released and absorbed.  This can lead to high blood levels of folic acid, which as Dr. Lynch and other researchers have shown, can impair the methylation cycle in people with MTHFR and other genes.  What I have just discovered is that one important and often-overlooked source of this increased, UNMETABOLIZED Folic Acid is a raging Gut Infection!

This gut infection, aka SIBO, is an infection made up of non-infectious bacteria.  Meaning, its not an infection in the traditional sense, its an overgrowth of something that should normally be there, only exists in way too high of a quantity.  This is a problem since the bacteria down there can produce folic acid while at the same time causing all kinds of other digestive issues.

As I will show in the next video, SIBO can be caused by antibiotics, proton-pump inhibitor drugs, chronic leaky gut, ileocecal valve dysfunction, and chronic stress.  All of these triggers make it easier for the bacteria that normally lives in the colon, to make its way up into the small intestine where it doesn’t belong.  In fact, those individuals who have been on long-term antibiotics and/or proton-pump inhibitors often have the most challenging methylation issues.  The reason is that those drugs – antibiotics and acid reflux medication – make is much more likely to get a Small Intestine Bacterial Overgrowth.  And with SIBO comes excess folic acid, low b12 and a host other malnutrition/methylation issues.

Common health issues associated with SIBO include:

  • Low B12
  • High Folic Acid
  • Low Iron
  • Low Vitamin A, D, E, and K
  • Low Omega 3’s and other fatty acids
  • Difficulty gaining weight / failure to thrive
  • Gas
  • Diarrhea
  • Bloating
  • Abdominal Pain
  • Food in stool
  • Fat in stool
  • GB disease
  • Acid reflux
  • Malabsorption
  • Difficuly losing weight / obesity
  • and much more…

Many patients with methylation issues are dealing with the symptoms I’ve just listed above.  The take away point is to realize that in order to heal the methylation cycle, you have to heal the gut.  Every supplement you take, every food, every beverage interacts with the bacteria in your gut.  If the gut is imbalanced and you have too much bacteria in the small intestine, you are likely going to have luke warm results until you treat the gut problem.  If someone is suffering from a digestive problem like SIBO with symptoms like the ones I’ve listed, it is going to be very difficult to fix the methylation issues until the gut is working better.

Because the bacteria in the small intestine have the ability to produce folic acid, many patients are suffering because their body is full of folic acid and they don’t have enough folate.  Dr. Lynch demonstrates that because folic acid can starve the cell of needed folate (L 5-methyltetrahydrofolate) it can weaken the methylation cycle.  And since the SIBO infection continously produces folic acid, I’m not sure taking more folate is the answer.

In our office we have learned to treat the gut first, making sure to clear out the gut infection before embarking on supporting methylation.  Through trial and error we have learned that until the gut bacteria is working properly, there cannot be methylation balance.  The research discussed in the videos above also supports this idea as well.  We all know having too much folic acid can create an imbalance.  I believe the many patients with digestive symptoms like bloating, reflux, gas, and abdominal pain of a chronic nature are suffering from some form of SIBO.  I also believe that unmetabolized folic acid is a SIDE EFFECT of a gut infection.  Even if someone avoids fortified foods and high doses of folic acid, just having SIBO means they can still be absorbing folic acid directly from the gut itself.

If you or someone you know is dealing with digestive issues and is concerned about methylation problems, then please contact my office.  We have developed effective, safe, and natural approaches to clear the gut infection quickly to make way for the more long-term healing methylation support.  Once the gut has been restored and is working properly, the body will be able to heal much more effectively and the methylation cycle can then be addressed.

Yours In Health,

Dr. Rostenberg

By studying the current peer-reviewed research, Dr. Rostenberg has discovered powerful, natural strategies to restore your gut and heal your body.  He can help you uncover the genetic or root causes of your health problem and find a natural solution!  If you would like help with your methylation genetics to improve your gut function and reduce/eliminate your symptoms, please contact Dr. Rostenberg at Red Mountain Natural Medicine today. Phone 208-322-7755. Email Website