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Tag Archives: Depression

When Your Gut Has Too Little: The Depressed Microbiome

UncategorizedBy Dr. RostenbergSeptember 26, 2026Leave a comment

When people have digestive problems, we often assume there is too much bacteria—some kind of bacterial overgrowth or dysbiosis that needs to be reduced. But there is another possibility that gets much less attention: sometimes there simply aren’t enough microbes in the gut. I think about the microbiome much like I think about many other…

The Tryptophan Steal: What Quinolinic Acid Can Tell Us About Stress, Inflammation, and Brain Health

UncategorizedBy Dr. RostenbergSeptember 9, 2026

Have you ever wondered why chronic stress, inflammation, poor sleep, or illness can seem to affect your mood and mental clarity all at once? One piece of the puzzle may be the way your body uses tryptophan, an essential amino acid involved in producing serotonin, melatonin, and other important compounds. Under certain conditions, more tryptophan…

How a Vegan Diet Can Starve the Brain of Cholesterol

UncategorizedBy Dr. RostenbergAugust 5, 2026

A vegan diet is often promoted as one of the healthiest ways to eat, but that doesn’t mean it’s the healthiest choice for every person—or that it remains beneficial over the long term. In some individuals, years of avoiding animal foods can contribute to chronically low cholesterol and inadequate fat intake, potentially affecting brain function,…

ADD, ADHD, and Low Dopamine

Introduction to Methylation and MTHFRBy Dr. RostenbergMarch 18, 2019

  Research this concept by joining your colleagues at WellPower, an online learning platform built for functional medicine practitioners, naturopaths, chiropractors and nutritionists. Learn More I’m excited to bring you a new video. I know it’s been quite a while since I was able to publish one. All I can say is it’s been an…

The FUT2 Genes – A Hidden Cause of Leaky Gut and Leaky Brain

MTHFR and the Gut-Brain ConnectionBy Dr. RostenbergJuly 22, 20179 Comments

  Researching methylation is a fascinating area of study that ties together many different systems of our body. While MTHFR, COMT, and MAO genes are very well-known, they are other lesser known genes that impact our health as well. In this video I am sharing with you my latest research into a gene called FUT2…

MTHFR and Depression – The Folate and BH4 Connection

Introduction to Methylation and MTHFRBy Dr. RostenbergMay 8, 201635 Comments

  Introduction Many people who are looking at their genetics are often motivated by the problem of depression.  Of course like many common health problems depression is now a big business in our society.  Pharmaceutical companies rake in billions of dollars producing drugs to try and treat this problem.  Unfortunately in the vast majority of…

Organic Acid Test – An Essential Tool for Gut-Methylation Problems

Home Slider, MTHFR and the Gut-Brain ConnectionBy Dr. RostenbergOctober 26, 201519 Comments

  This article is a brief overview of why I think the Organic Acid Test from Great Plains Laboratory is the best test for gut & methylation issues.   It is important to point out that I am not in any way affiliated with Great Plains Lab – but I do use it regularly and…

Leaky Gut, Leaky Brain: How Gut Problems Create Brain Problems

Health LecturesBy Dr. RostenbergSeptember 23, 2015

  Whether you are suffering from depression, anxiety, insomnia, chronic pain, brain fog or other concerns, optimizing your gut function is key to restoring your health. Gut bacteria produce vitamins, neurotransmitters and other molecules that can impact every cell and organ in our body.  If our gut isn’t in an optimum condition, then the healing…

Treating COMT and MAO: the Hormonal Cause of Stress and Anxiety

Pregnancy, Hormones, Methylation and MoreBy Dr. RostenbergAugust 27, 201527 Comments

  Introduction Optimizing methylation pathways means going further than just deciding how much B12 or folate a person needs. Seeking to optimize methylation pathways means you must go far beyond just looking at MTHFR and see all the genes and biochemicals that are impacting our health. And we cannot optimize genes without understanding how our…

Treating COMT and MAO: How COMT Influences the Brain

MTHFR and the Gut-Brain ConnectionBy Dr. RostenbergJuly 15, 201518 Comments

  Everyone has felt the negative effects of stress in their lives, yet not everyone responds to stress in the same way.  While our life experience has a great deal of influence on our perception of stress, certain genes make us more or less sensitive to stress.  One big reason why stress affects each of…

Adrenal Fatigue: The 7 Signs of Adrenal Stress

Health Lectures, What’s NewBy Dr. RostenbergJune 24, 201511 Comments

  Adrenal fatigue is the most over-looked and unrecognized health condition in our society. Join Dr. Rostenberg for this information-packed presentation on how to identify the 7 Signs of Adrenal Stress. Symptoms such as dizziness, fatigue, poor sleep, weak immune system, hormone imbalance, and blood sugar issues are all related to adrenal stress.

The Cholesterol Connection: Learn the Hidden Truth Behind this Amazing Molecule

Health Lectures, What’s NewBy Dr. RostenbergApril 13, 20154 Comments

  Whether you have methylation problems or a chronic disease of some kind, making sure your cholesterol levels are optimized is key for the healing process.  New science is challenging the idea that high cholesterol is bad and low cholesterol is good.  We’ve been “managing” cholesterol levels for 50 years and we are getting sicker,…

Optimizing Genes, Optimizing Lives – January 2015

Health Lectures, What’s NewBy Dr. RostenbergMarch 1, 2015

There is a reason why people in this society are chronically ill and sick.  We all know that there is no shortage of drugs and surgeries in this country; we aren’t suffering from a lack of access to pharmaceutical drugs.  What we are dealing with is a lack of understanding of what the body actually…

A Genetic Cause of Pain and Anxiety – COMT, MAO and MTHFR

Home Slider, MTHFR and the Gut-Brain ConnectionBy Dr. RostenbergNovember 4, 201468 Comments

  Do you find yourself worrying excessively about the future,  about money or about fearful things in general?  Does a small amount of stress cause you to feel very stressed out?  Do you feel good while you exercise, but afterwards feel drained and worn out?  Are you easily agitated, nervous or upset?  Is your behavior…

Are You Tired or Toxic? The 5 Steps to Natural Detoxification

Health LecturesBy Dr. RostenbergJuly 6, 20141 Comment

  Are you tired or toxic? That is a fair question since many symptoms of toxic overload are commonly mislabeled as digestive issues, insomnia, chronic fatigue or even allergies.  Our bodies can detoxify the pollutants that exist in our modern world.  But in order to do that, our nutrition, our biochemistry, and our methylation pathways…

MAO-A – Understanding the SNP

MTHFR and the Gut-Brain Connection, UncategorizedBy Dr. RostenbergJune 12, 201459 Comments

One of the best parts of researching methylation is meeting people who ask very good questions.  One very good question came up the other day about MAO-A and whether or not it was sped up or slowed down.  This question is important considering how much impact the MAO system has on how we handle stress…

Research Articles on Methylation

Introduction to Methylation and MTHFRBy Dr. RostenbergJune 2, 20142 Comments

Good Morning, Today I am posting two published research articles about methylation that I have written in the last couple of years.  The first article is called Methylation and the Physical Exam.  It describes what to look for on the outside of the body if you suspect someone has a methylation problem.  I would also…

How to Balance COMT and MAO in the Brain

MTHFR and the Gut-Brain ConnectionBy Dr. RostenbergMay 7, 201474 Comments

https://www.youtube.com/watch?v=8qezmdDnY0s   In our last video Dr. Rostenberg laid out the fundamentals of how COMT and MAO polymorphisms affect our brain.  This video expands on these ideas and explains why and how methylation nutrients can heal the imbalanced brain.  The peer-reviewed research is clear that proper methylation is needed for normal brain function.  It also…

COMT and MAO in the Brain

MTHFR and the Gut-Brain ConnectionBy Dr. RostenbergMay 5, 201410 Comments

https://www.youtube.com/watch?v=aPsHxqBbACs   Have you ever noticed that people with methylation issues are usually very smart? It has a lot to do with having difficulty breaking down neurotransmitters. Having SNPs is not always a curse; it can bless you with attributes as well. COMT is a definitely contender for such a double-edged sword. It can keep…

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